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KMID : 1145720180060020279
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Korean Herbal Medicine Informatics
2018 Volume.6 No. 2 p.279 ~ p.288
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Analysis of the epigenome research trends and study on utilization of Korean Medicine
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Kim Chul
Seong Bo-Seok
Jang Yun-Ji
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Abstract
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The epigenesis is a phenomenon in which genetic information is expressed differently due to inherited factors such as environment, habit, and virus infection without changing the gene base sequence itself. Although many researchers could reveal many secrets of life through deciphering the human genome sequence, many studies using epigenetic have been attempted because genome had difficulty in explaining the various disease incidence. Large-scale projects are being actively carried out globally, and Korea is also participating in this project. We investigated what kind of research was carried out internationally using the epigenome and analyzed the technical factors that are needed to start the study of the epigenetic genome in this paper. We investigated applicable research areas using these techniques and introduced one epigenome project that our team has actually done. Our study used integrated network between DNA methylation and expression, identify epigenetic regulating network hub genes associated with anti-asthmatic effects by D. sophia seed extract (DSE) treatment in OVA-induced mouse model. We hope that the results of this study will lead to the development of diverse epigenetic studies in the field of Korean medicine.
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KEYWORD
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epigenome, epigenetic research, trend analysis, technical analysis
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